If I have used alcohol or drugs like marijuana, will my effect be the same as other men?

No. You will use up the testosterone more quickly because your liver is activated and it metabolizes testosterone with the same enzymes that metabolize alcohol and drugs. Marijuana increases prolactin, the hormone that increases breast size in men and women. Prolactin not only decreases your testosterone level but decreases your sex drive, ejaculatory function and sexual stamina. It is expected that if you take testosterone, you should stop using marijuana altogether and decrease or stop alcohol consumption.